Auburn's AdjO is No. 16, AdjD is No.44. So, there's some wiggle room.— Sam Butler (@_sam_butler) March 11, 2018
CofC's AdjO is No. 87, though, and their AdjD is No. 167.
So, if you're going by the numbers, an upset is v unlikely. But it could happen (Louisville v. Morehead St in 2012 outlier)