I think you could have an individual who knows more about both teams than anyone else in the entire world and they wouldn't be able to pick this game with any significant accuracy. It really all depends if "good" shooting Iowa shows up (call it >33% from 3). If they do, the Tigers are in trouble. If they don't, it could be an easy win for Auburn. If Iowa shoots >50% from three, then it should be a Hawkeye blowout. As I've mentioned above, this is not likely to happen as their away from home shooting has been pretty miserable (with the exception of the Indiana game).
Best of luck to you guys and safe travels for those who are going to the game. I'm picking Auburn in my multiple pool brackets.